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Arch Iran Med. 2020;23(1): 44-52.
PMID: 31910634
  Abstract View: 194
  PDF Download: 245

Systematic Review

Fecal Microbiota in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: A Systematic Review

Zahra Mohammadi 1,2, Hossein Poustchi 1,2, Nazgol Motamed-Gorji 2, Sareh Eghtesad 2, Azita Hekmatdoost 3, Parastoo Saniee 4, Shahin Merat 1,2 *

1 Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Liver and Pancreatobiliary Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
*Corresponding Author: Shahin Merat, MD; Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Tel: 02182415238; Fax: 02182415400; Email: shahin.merat@gmail.com

Abstract

Background: With the increasing prevalence of obesity, non-alcoholic fatty liver disease (NAFLD), has become a frequent cause of chronic liver disease, often leading to cirrhosis. In recent decades, gut microbiota have been evaluated as an effective factor in NAFLD pathogenesis, causing steatohepatitis by involving the host immune system. The aim of this study is to evaluate gut microbiota dysbiosis in NAFLD/NASH patients in comparison to healthy controls.

Methods: We conducted a systematic search of published studies that have examined the composition of gut microbiota in relation to NAFLD. PubMed, Scopus and ISI Web of Science were searched. After the exclusion of irrelevant studies, 15 eligible studies were included and summarized.

Results: Overall, some studies reported the composition of microbiota at the phyla level, while others reported them at smaller subgroups; the results of studies were contradictory in some cases.

Conclusion: Overall, study findings indicate a relationship between microbial composition and NAFLD. Study methods and sequencing techniques influenced these results.

Keywords: Fecal Microbiota, Non-alcoholic fatty liver disease, Non-Alcoholic Steatohepatitis
Cite this article as: Mohammadi Z, Poustchi H, Motamed-Gorji N, Eghtesad S, Hekmatdoost A, Saniee P, et al. A systematic review on fecal microbiota in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Arch Iran Med. 2020;23(1):44–52.
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Submitted: 25 Jun 2019
Accepted: 02 Sep 2019
ePublished: 01 Jan 2020
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