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Arch Iran Med. 2020;23(1): 1-6.
PMID: 31910628
  Abstract View: 255
  PDF Download: 366

Original Article

Incidence of Malignant Brain and Central Nervous System Tumors in Golestan, Iran, 2004–2013

Marzieh Araghi 1, Gholamreza Roshandel 2 * , Susan Hasanpour-Heidari 2, Abdolreza Fazel 3, Seyed Mehdi Sedaghat 4, Amirhoushang Pourkhani 5, Vahideh Kazeminejhad 6, Adalberto Miranda-Filho 1, Freddie Bray 1, Melina Arnold 1

1 Section of Cancer Surveillance, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, 69372 CEDEX 08, France
2 Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
3 Omid Cancer Research Center, Omid Preventive and Health Promotion Center, Golestan University of Medical Sciences, Gorgan, Iran
4 Deputy of Public Health, Golestan University of Medical Sciences, Gorgan, Iran
5 Department of hematology/oncology, Golestan University of Medical Sciences, Gorgan, Iran
6 Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Abstract

Background: Brain and other central nervous system (CNS) tumors represent almost 3% of all new cancer cases worldwide and comprise a heterogeneous group of tumors with varying epidemiologic and clinical characteristics. The aim of this study is to present the distribution and trends in brain and other CNS cancer incidence in Golestan, Iran during a 10-year period.

Methods: Data on primary brain and other CNS cancers diagnosed between 2004 and 2013 were obtained from the Golestan population-based cancer registry (GPCR) dataset. We computed age-standardized incidence rates (ASRs) per 100000 personyears. In order to assess changes in incidence over time, we calculated the estimated annual percentage change (EAPC) and corresponding 95% confidence intervals (CIs) to detect significant trends.

Results: Over the 10-year period (2004-2013), the incidence of brain and other CNS cancer was observed to increase for all ages (EAPC: 1.13, 95% CI: -6.06, 8.87). After 2008, the trends appear to have stabilized. Incidence rates were higher in males than females (ratio: 1.2) and glioblastoma was the most common tumor subtype (15.1% of all malignant tumors).

Conclusion: Trends and patterns in the burden of brain and other CNS cancer require careful monitoring alongside future research to increase our understanding of potential risk factors.

Keywords: Brain tumors, Central nervous system tumors, Epidemiology, Incidence rates
Cite this article as: Araghi M, Roshande G, Hasanpour-Heidari S, Fazel A, Sedaghat SM, Pourkhani A, et al. Incidence of malignant brain and central nervous system tumors in Golestan, Iran, 2004–2013. Arch Iran Med. 2020;23(1):1–6.
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Submitted: 11 May 2019
Accepted: 23 Sep 2019
ePublished: 01 Jan 2020
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