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Arch Iran Med. 2020;23(5): 312-318.
doi: 10.34172/aim.2020.20

Scopus ID: 85084390865
  Abstract View: 576
  PDF Download: 295

Original Article

Effect of Aminophylline in Preventing Renal Dysfunction among Neonates with Prenatal Asphyxia: A Clinical Trial

Maryam Saboute 1 ORCID logo, Javad Balasi 2 ORCID logo, Saleheh Tajalli 3 ORCID logo, Mahmoud Hajipour 4 ORCID logo, Shaghayegh Heshmat 2, Nasrin Khalesi 2* ORCID logo, Leila Allahqoli 5 ORCID logo

1 Department of Neonatology, Akbar Abadi Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran
2 Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran
3 School of Nursing and Midwifery, Iran University of Medical Sciences, (IUMS), Tehran, Iran
4 Student Research Committee, Epidemiology Department, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Endometriosis Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
*Corresponding Author: Nasrin Khalesi, MD; Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran. Email: nasrinkhalessi@yahoo.com

Abstract

Background: As there are different views on the effects of aminophylline on neonatal renal function, we intended to observe the effects of aminophylline on renal dysfunction in neonates with prenatal asphyxia.

Methods: This randomized trial was conducted in the Obstetrics and Gynecology Hospital, Tehran, Iran, from June 2016 to May 2017, in neonates with moderate to severe asphyxia during birth. Fifty-six neonates were divided randomly into two groups. The intervention group received one dose of 5mg/kg slow intravenous aminophylline injection and the placebo group received 2 mL/kg of intravenous 10% solution of dextrose saline during the first hour of life. They were monitored and compared for renal functional indices, electrolytes, and complications of asphyxia during the three days of life.

Results: The mean of Cr (37.9 ± 8.8 vs 38.5 ± 9.4 and 20.8 ± 4.8 vs 30.1 ± 5.2 μmol/L), GFR (21.55 ± 4.7 vs 20.25 ± 4.4 and 30.8 ± 7.1 vs 20.1 ± 6.5 mL/minute/1.73 m2 ), Na (135.1 ± 12.4 vs134.5 ± 11.2 and 128.9 ± 11.5 vs 134.2 ± 10.9 mEq/L), and urine output (98.2 ± 25 vs 96.8 ± 23 and 148.7 ± 35 vs 108.8 ± 20 cc) were in the aminophylline treated and placebo group on the 1st and 3rd days, respectively. The mean difference of Cr (-9.3 (-8.9; -9.7) μmol/L); (P = 0.02), GFR (10.7 (10.1; 11.3) mL/minute/1.73 m2 ) (P = 0.009), Na (-5.3 (-5.9; -4.7) mEq/L) (P = 0.002), and urine volume (39.9 (24.9; 54.9) cc) (P = 0.001) presented statistically significant differences on the third day between the intervention and placebo group.

Conclusion: Aminophylline was effective in preventing renal dysfunction in neonates with asphyxia. Neonates who received aminophylline indicated a significant improvement in GFR and urine output on the first day of life.

Keywords: Asphyxia, Aminophylline, Renal Function
Cite this article as: Saboute M, Allahqoli L, Balasi J, Tajalli S, Hajipour M, Heshmat S, et al. Effect of aminophylline in preventing renal dysfunction among neonates with prenatal asphyxia: a clinical trial. Arch Iran Med. 2020;23(5):312–318. doi: 10.34172/ aim.2020.20.
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Submitted: 04 May 2019
Accepted: 26 Jan 2020
ePublished: 01 May 2020
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