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Arch Iran Med. 2020;23(2): 104-112.
PMID: 32061073
  Abstract View: 307
  PDF Download: 264

Original Article

Accuracy of Magnetic Resonance Spectroscopy Techniques in Prostate Cancer and Prostatitis

Mansour Zabihzadeh 1,2,3 ORCID logo, Jafar Fatahi Asl 4, Zahra Farzanegan 2 * , Seyed Mokhtar Hoseini 5, Mohsen Sarkarian 5, Bahman Cheraghian 6, Shapour Dahaz 7, Mohammad Momen Garibvand 8

1 Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Radiology, School of Para Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Department of Urology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6 Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7 Department of Anatomy, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
8 Department of Radiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Background: Considering the non-invasive nature of magnetic resonance spectroscopy (MRS) and its ability to detect prostate lesions, the present study aimed to investigate the accuracy of MRS techniques in distinguishing between prostate cancer (PCa) and prostatitis.

Methods: Thirty-three patients (18 patients with PCa and 15 patients with prostatitis) were recruited for this study. Magnetic resonance imaging (MRI) and MRS were performed using 1.5-T system GE- modle Optima 450 Discovery (GE Medical Systems, US). The (Cho+Cr)/Cit ratio of hypointense T2 areas were calculated. The diagnostic accuracy including sensitivity and specificity indices, with 0.95 confidence interval as well as PPV and NPV were calculated for each variable. The receiver operating characteristic (ROC) area under the curve (AUC) was outlined and investigated. The mean quantitative values between the two groups (PCa and Prostatitis) were compared using independent t test.

Results: The mean ratios of Cho+Cr/Cit in PCa was 1.54 ± 0.63 and 0.83 ± 0.48 for PCa and prostatitis, respectively, indicating a significant statistical difference (P = 0.00). A reduction in citrate was seen in both PCa and prostatitis tissue. Significant elevation in choline peak was shown for PCa. Moreover, creatinine level was low in both normal tissue and PCa without significant difference. Sensitivity, specificity, accuracy, PPV and NPV of MRS were 94.4% (95% CI, 74.2–99), 80% (95% CI, 54.8–93), 96%, 85% and 92.4%, respectively.

Conclusion: The results of this study indicate an acceptable level of sensitivity, specificity and accuracy of MRS in the differential diagnosis of PCa and prostatitis.

Keywords: Magnetic resonance spectroscopy, Prostate cancer, Prostatitis
Cite this article as: Zabihzadeh M, Fatahi Asl J, Farzanegan Z, Hoseini SM, Sarkarian M, Cheraghian B, et al. Accuracy of magnetic resonance spectroscopy techniques in prostate cancer and prostatitis. Arch Iran Med. 2020;23(2):104–112.
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Submitted: 12 Apr 2019
Accepted: 21 Oct 2019
ePublished: 01 Feb 2020
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