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Arch Iran Med. 2020;23(1): 23-30.
PMID: 31910631
  Abstract View: 196
  PDF Download: 233

Original Article

Socio-demographic Characteristics, Biochemical and Cytokine Levels in Bulimia Nervosa Candidates for Sleeve Gastrectomy

Mohsen Tabasi 1,2, Taha Anbara 3, Seyed Davar Siadat 4, Jamil Kheirvari Khezerloo 5, Fezzeh Elyasinia 6, Saeed Bayanolhagh 7, Seyed Abbas Sadat Safavi 3, Mohammad Reza Yazdannasab 4, Ahmadreza Soroush 8, Saeid Bouzari 1 * ORCID logo

1 Department of Molecular Biology, Pasteur Institute of Iran, Pasteur Ave., Tehran, Iran
2 Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
3 Tehran Laparoscopic Surgery Department, Erfan Niayesh Hospital, Tehran, Iran
4 Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
5 Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
6 Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
7 Iranian Research Center of HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran
8 Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Eating disorders (EDs) are widely known by abnormal eating behaviors associated with significant medical complications. Bulimia nervosa (BN) is an eating disorder characterized by uncontrolled episodes of overeating typically followed by some form of compensatory behaviors. We aimed to determine the relationships between socio-demographic characteristics, biochemical markers, and cytokine levels in BN candidates for laparoscopic sleeve gastrectomy (LSG).

Methods: A case-control study was designed among 76 BN participants of Iranian descent who were candidates for LSG based on defined criteria for Bulimia by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). The healthy control subjects (n = 42) were selected at random from academic staff in the college. Moreover, levels of biochemical parameters and serum cytokines were measured in serum samples.

Results: Routine consumption of caffeine (odds ratio [OR] = 3.1, 95% CI: 1.23–6.41, P = 0.013), tobacco (OR = 1.8, 95% CI: 0.67–3.57, P = 0.03), and alcohol (OR = 3.6, 95% CI: 0.84–7.18, P = 0.048), and depression history (OR = 2.8, 95% CI: 0.76– 5.79, P = 0.037) were substantially more common among patients with bulimia. Also, the serum levels of fasting blood sugar (P<0.001), HbA1c (P = 0.04), cholesterol (P = 0.03), triglycerides (P = 0.01), blood urea nitrogen (P = 0.03), and pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α were significantly higher in BN candidates for LSG (P ≤0.001).

Conclusion: Our findings reveal that lifestyle-related risk factors and a depression history were both related with a significantly increased risk of BN among the candidates for LSG. Furthermore, there is a relationship between clinical characteristics as well as levels of various biochemical and cytokines parameters in serum of BN patients.

Keywords: Biological markers, Bulimia nervosa, Cytokines, Eating disorders, Gastrectomy
Cite this article as: Tabasi M, Anbara T, Siadat SD, Kheirvari Khezerloo J, Elyasinia F, Bayanolhagh S. Socio-demographic characteristics, biochemical and cytokine levels in bulimia nervosa candidates for sleeve gastrectomy. Arch Iran Med. 2020;23(1):23–30.
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Submitted: 28 Mar 2019
Accepted: 23 Sep 2019
ePublished: 01 Jan 2020
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