Arch Iran Med. 2022;25(8): 547-551.
doi: 10.34172/aim.2022.87
  Abstract View: 119
  PDF Download: 104

Original Article

Factors Associated with the Transition Time to Full Enteral Feeding in Newborns with Hypoxic Ischemic Encephalopathy

Asli Okbay Gunes 1* ORCID logo, Nilgun Karadag 1, Sevilay Topcuoglu 1, Elif Ozalkaya 1, Handan Hakyemez Toptan 1, Emre Dincer 1, Hakan Cakir 1, Guner Karatekin 1

1 University of Health Sciences, Zeynep Kamil Maternity and Children’s Training and Research Hospital -Istanbul, Turkey
*Corresponding Author: Corresponding Author: Asli Okbay Gunes, MD, Email: , Email: asliokbay@gmail.com


Background: We aimed to assess the factors associated with the transition time to full enteral feeding (FEF) in newborns with hypoxic ischemic encephalopathy (HIE) undergoing therapeutic hypothermia.

Methods: We obtained data retrospectively from medical records of the neonates diagnosed with HIE and treated by therapeutic hypothermia to evaluate the factors associated with transition time to FEF.

Results: Sixty-one neonates were included in the study. The median gestational age (GA) and birth weight were 39 (37–40) weeks and 3245 (2715–3575) grams, respectively. APGAR scores at the first and fifth minutes were 3 (1–5) and 6 (4–7), respectively. Fifty-seven (93.4%) of the newborns were diagnosed as having moderate HIE, and 4 (6.6%) of them had severe HIE. Transition time to FEF was found to be negatively correlated with gestational week (r, P: -0.280, 0.029) and birth weight (r, P: -0.315, 0.013); and positively correlated with lactate (r, P: 0.295, 0.044), BUN (r, P: 0.285, 0.026) and creatinine levels (r, P: 0.345, 0.007); duration of invasive (r, P: 0.565, 0.0001) and non-invasive mechanical ventilation (r, P: 0.261, 0.042), use of antibiotics (r, P: 0.556, 0.0001) and inotropic agents (r, P: 0.524, 0.0001) and hospitalization (r, P: 0.654, 0.0001).

Conclusion: Clinicians should be more careful while starting to feed babies undergoing therapeutic hypothermia with higher lactate levels and impaired renal functions, and should be encouraged to feed clinically stable neonates with HIE as soon as possible, as the transition time to FEF could be related with better clinical outcomes.

Cite this article as: Gunes AO, Karadag N, Topcuoglu S, Ozalkaya E, Toptan HH, Dincer E, et al. Factors associated with the transition time to full enteral feeding in newborns with hypoxic ischemic encephalopathy. Arch Iran Med. 2022;25(8):547-551. doi: 10.34172/aim.2022.87
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Submitted: 16 Apr 2021
Revision: 20 Jul 2021
Accepted: 20 Aug 2021
ePublished: 01 Aug 2022
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