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Arch Iran Med. 2022;25(2): 105-111.
doi: 10.34172/aim.2022.17
  Abstract View: 646
  PDF Download: 386

Original Article

Short- and Long-term Myocardial Infarction Survival Rate According to the Type of Drugs Prescribed at the Time of Discharge: A Study Using Iran National Registry Data

Samaneh Mozaffarian 1 ORCID logo, Niloufar Taherpour 2 ORCID logo, Mohammad Sistanizad 2,3 ORCID logo, Mohammad Aghaali 4 ORCID logo, Seyed Saeed Hashemi Nazari 5* ORCID logo

1 Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Community Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran
5 Associate Professor of Epidemiology, Prevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: *Corresponding Author: Seyed Saeed Hashemi Nazari, MD, MPH, PhD; School of Public Health and Safety, Shahid Beheshti University of Medical Science, Daneshjoo Blvd, Evin Ave, Tehran, Iran. Postal code: 198353-5511. Tel: +98 (21) 22431993; Email: , Email: saeedh_1999@yahoo.com

Abstract

Background: Coronary artery disease is among the first causes of death in Iran. Secondary prevention with drug therapy is recommended following acute myocardial infarction (MI) to reduce the risk of new cardiovascular events and death.

Methods: This is a retrospective cohort study on data collected from 21181 cases of MI recorded by the MI Registry of Iran from 2013 to 2014. Ten therapies that were prescribed to patients at the time of discharge were divided into 6 groups. Survival rates were estimated using the Kaplan-Meier method and Cox regression analysis.

Results: The most common MI location was in the anterior wall (31.87%). Anticoagulants, aspirin, clopidogrel were the most common prescribed medications (94.73%). Overall, 28-day (short-term) and 3-year survival rates were 0.95 (95% CI: 0.95–0.96) and 0.82 (95% CI: 0.81–0.82). In non-ST-elevation myocardial infarction (NSTEMI) patients, the lowest short- and long-term survival rates were observed when diuretic, anticoagulants/ aspirin and clopidogrel, beta-blockers and statins medication were simultaneously taken and the highest short- and long-term survival rates were observed in patients who took anticoagulants, aspirin and clopidogrel, nitrate agent and calcium blockers, beta-blockers and statins medication. In STEMI patients, the lowest short- and long-term survival rates were observed when diuretic, anticoagulants, aspirin and clopidogrel, nitrate agent and calcium blockers, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) were simultaneously taken. The highest short- and long-term survival rates were observed in patients who received anticoagulants, aspirin and clopidogrel, nitrate agent and calcium blockers, beta-blockers, statins, ACEIs and ARBs.

Conclusion: Prescription of the best combination of drugs, in addition to adherence to a healthy lifestyle and medication, can improve the survival rates after MI.



Cite this article as: Mozaffarian S, Taherpour N, Sistanizad M, Aghaali M, Hashemi Nazari SS. Short- and long-term myocardial infarction survival rate according to the type of drugs prescribed at the time of discharge: a study using iran national registry data. Arch Iran Med. 2022;25(2):105-111. doi: 10.34172/aim.2022.17
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Submitted: 18 Mar 2021
Revision: 13 Jun 2021
Accepted: 21 Jun 2021
ePublished: 01 Feb 2022
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