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Arch Iran Med. 2018;21(5): 208-212.
PMID: 29738264
Scopus ID: 85054085146
  Abstract View: 2111
  PDF Download: 1216

Original Article

The Prevalence of PCR-Confirmed Pertussis Cases in Palestine From Archived Nasopharyngeal Samples

Kamal Dumaidi 1, Amer Al-Jawabreh 1,2

1 Department of Medical Lab sciences, Faculty of Allied Health sciences, Arab American University, Palestine
2 Al-Quds Public Health Society, Jerusalem, Palestine
*Corresponding Author:

Abstract

Background: Pertussis caused by Bordetella pertussis is a vaccine-preventable disease causing whooping cough in humans of all ages. This study reports infection rate of pertussis in Palestine between the years 2004-2008 from archived nasopharyngeal samples collected from clinically- suspected cases.

Methods: A convenience archived DNA samples collected from 267 clinically-suspected pertussis cases were investigated for B. pertussis. Laboratory diagnosis was done by examining all DNA samples using polymerase chain reaction (PCR).

Results: Approximately 49% (130/267) were confirmed by PCR. A pertussis peak was shown to occur in 2008 with 77% (100/130) of PCR-confirmed cases isolated in that year. PCR-confirmed cases existed in all Palestinian districts with highest rate in Ramallah, Bethlehem, Jenin and Al-Khalil. Half of the PCR-confirmed cases (68/130) were less than 2 months old. The positivity rate among who had three doses of vaccine (at 2, 4 and 6 months) was 38%, and became 50% with the fourth dose at 12 months.

Conclusion: The prevalence of pertussis was found to be significantly high among infants less than 2 months old. Active pertussis surveillance using rapid PCR assays is essential, as it is helpful in prompt diagnosis and treatment of patients with pertussis. 


Cite this article as: Dumaidi K, Al-Jawabreh A. The prevalence of PCR-confirmed pertussis cases in palestine from archived nasopharyngeal samples. Arch Iran Med. 2018;21(5):208–212.
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Submitted: 10 Dec 2017
Accepted: 08 Apr 2018
ePublished: 01 May 2018
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