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Arch Iran Med. 2018;21(5): 185-190.
PMID: 29738261
Scopus ID: 85054092792
  Abstract View: 2200
  PDF Download: 1392

Original Article

The Significance of the Stromal Response in Breast Cancer: An Immunohistochemical Study of Myofibroblasts in Primary and Metastatic Breast Cancer

Alale Roozdar 1, Malcolm M. Hayes 2, Bahram Pourseyedei 3, Hamid Zeinalinejad 3, Manzumeh Shamsi Meymandi 1, Bahram Dabiri 1, Shahriar Dabiri 1*

1 Pathology and Stem Cells Research Center, Pathology Department, Afzalipour Kerman Medical Sciences University, Kerman, Iran
2 Pathology Department, B.C. Cancer Agency, University of British Columbia, Vancouver, Canada
3 Surgery Department, Afzalipour Kerman Medical Sciences University, Kerman, Iran
*Corresponding Author: *Corresponding Author: Shahriar Dabiri, MD, FIAC; Pathology and Stem Cells Research Center, Pathology Department, Afzalipour Kerman Medical Sciences University, Kerman, Iran. Address: 22th Bahman Blvd; P. O. Box 444, Tehran, Iran. Tel: +98-3433257112, Email:, Email: dabiri12@yahoo.com

Abstract

Background: Gene expression profiling of breast cancer has demonstrated the importance of stromal response in determining the prognosis of invasive breast cancer. The host response to breast cancer is of increasing interest to pathologists and may be a future focus for novel pharmacological treatments.

Methods: This study describes the pattern of distribution of stromal myofibroblasts using immunostains for CD10 and smooth muscle actin (SMA) in 50 primary breast cancers and their matched nodal metastases (68.6% nodes positive and 31.4% nodes negative). The stroma within the tumor (intratumoral) and at the advancing tumor edge (peri-tumoral) was studied in both primary and nodal sites. A simple quantitative scoring system was employed for both immunostains. The correlation between expression of these markers by stromal cells and standard pathological prognostic factors of stage, grade, hormone receptor and Her-2 status was analysed.

Results: SMA-positive stromal cells were more abundant in peri-tumoral stroma compared with intratumoral stroma in both primary and metastatic lesions. SMA expression in the lymph node metastases showed a significant correlation with tumor stage. SMA expression in peri-tumoral stroma correlated with Her-2 status.

Conclusion: The results of this study suggest that myofibroblasts, particularly those expressing SMA, might potentiate the progression of the carcinomatous process especially in nodal metastases. Thus these cells may be a potential therapeutic target. 


Cite this article as: Roozdar A, Hayes MM, Pourseyedei B, Zeinalinejad H, Meymandi MS, Dabiri B,. The significance of the stromal response in breast cancer: an immunohistochemical study of myofibroblasts in primary and metastatic breast cancer. Arch Iran Med. 2018;21(5):185–190.
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Submitted: 18 Apr 2016
Accepted: 08 Apr 2018
ePublished: 01 May 2018
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