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Arch Iran Med. 2021;24(5): 409-418.
doi: 10.34172/aim.2021.59

Scopus ID: 85108851663
  Abstract View: 687
  PDF Download: 518

Review Article

Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the Evidence

Ahmad Shamabadi 1, Shahin Akhondzadeh 1*

1 Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Professor Shahin Akhondzadeh, PhD, Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar St., Tehran, Iran 13337. Tel: +98-21-55412222, Fax: +98-21-55419113, Email: s.akhond@tums.ac.ir

Abstract

Depression is a chronic and debilitating psychiatric disorder that affects 300 million people worldwide. Pharmacotherapy is one of the treatments. Due to delay in initiating treatment efficacy and the incomplete response to mono-drug therapy in one-third of patients, new approaches need to be considered. One of the ways to overcome this resistance to treatment and to enhance standard medical practice is to add complementary medicines. We aimed to document research progress from studies on integrative medicine for the treatment of depression. Review of PubMed and Scopus databases on the topic and a personal collection of the relevant publications are the sources for this study. Some of the nutraceuticals and complementary medicines in the treatment of depression will be reviewed. Supplements discussed in this review include S-adenosyl-methionine (SAMe), Crocus sativus (Saffron), carnosine, theanine, palmitoylethanolamide (PEA), tryptophan and 5-hydroxytryptophan (5-HTP), gemfibrozil, curcumin (the main active ingredient in turmeric), Hypericum perforatum (St John’s wort), Lavandula angustifolia (Lavender), and Cinnamomum tamala. Despite evidence in favor of the antidepressant effect of several supplements, their efficacy and tolerability should be evaluated and validated by further high-quality studies.
Keywords: Antidepressive agents, Traditional medicine, Nutraceuticals, Herbal medicine, Complementary therapies
Cite this article as: Shamabadi A, Akhondzadeh S. Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the Evidence. Arch Iran Med. Arch Iran Med. 2021;24(5):409-418. doi: 10.34172/aim.2021.59
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Submitted: 25 Nov 2020
Accepted: 27 Apr 2021
ePublished: 01 May 2021
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