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Arch Iran Med. 2018;21(1): 13-18.
PMID: 29664665
Scopus ID: 85044292503
  Abstract View: 2094
  PDF Download: 1306

Original Article

Genetic Variation in NFKB1 Gene Influences Liver Enzyme Levels in Morbidly Obese Women

Guven Yenmis 1,2, Tugba Soydas 2, Hulya Arkan 2, Ertugrul Tasan 3, Gonul Kanigur Sultuybek 4*

1 Acibadem Healthcare Services, Acibadem University Kerem Aydinlar Campus, Labgen, Atasehir, Istanbul, Turkey
2 Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Bezmialem Medical Faculty, Bezmialem University, Istanbul, Turkey
4 Department of Medical Biology, Istanbul Aydin Medical Faculty, Istanbul Aydin University, Istanbul, Turkey
*Corresponding Author: Corresponding Author: Gonul Kanigur Sultuybek, Department of Medical Biology, Istanbul Aydin Medical Faculty, Istanbul Aydin University, Besyol Mahallesi, Inonu Cd. No:38, 34295 Kucukcekmece/Istanbul. Cell Phone: +90-532-452-4456, Email: kanigur@istanbul.edu.tr

Abstract

Background: Morbid obesity (MO), characterized by low-grade inflammation, is associated with increased C-reactive protein (CRP). NF-KB is a candidate factor for inflammatory responses in inflammatory diseases such as obesity. The objective of our study was to investigate the relationship between NFKB1 gene variations and the risk of MO in the context of the high/normal level of liver enzymes such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP).

Methods: We analyzed the distribution of NFKB1 -94 ins/del ATTG (rs28362491) polymorphism using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP)and liver enzymes serum levels using ELISA in 182 MO patients with CRP level ≥20 mg/L and 200 healthy controls in a female Turkish population.

Results: We found that having ins/ins genotype of rs28362491 is a risk factor in both high level and normal level liver enzymes of ALT (P = 0.0335, P = 0.0134), AST (P = 0.0285, P = 0.0113) and ALP (P = 0.0079, P = 0.0363) whereas having ins/ins genotype of rs28362491 is a risk factor in only high-level liver enzyme of GGT (P = 0.0003).

Conclusion: Our results suggest that ins/ins genotype of SNP rs28362491 is linked to MO with high-level ALT, AST, ALP, and GGT. 


Cite this article as: BYenmis G, Soydas T, Arkan H, Tasan E, Sultuybek GK. Genetic variation in NFKB1 gene influences liver enzyme levels in morbidly obese women. Arch Iran Med. 2018;21(1):13–18.
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Submitted: 06 May 2017
Accepted: 18 Oct 2017
ePublished: 01 Jan 2018
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