Logo-aim
Arch Iran Med. 2018;21(1): 8-12.
PMID: 29664664
Scopus ID: 85044291204
  Abstract View: 2194
  PDF Download: 1477

Original Article

C-Reactive Protein Levels and Clinical Outcomes in Stroke Patients: A Prospective Cohort Study

Shahir Mazaheri 1, Elahe Reisi 1, Jalal Poorolajal 2*, Masoud Ghiasian 1

1 Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Modeling of Noncommunicable Diseases Research Center and Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Corresponding Author: Jalal Poorolajal, PhD; Modeling of Noncommunicable Diseases Research Center and Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran, Email: poorolajal@umsha.ac.ir

Abstract

Background: The C-reactive protein (CRP) level, as an early prognostic factor of functional outcome after stroke, may be of clinical importance. The aim of this study was to determine the prognostic value of CRP on functional outcome and death in stroke patients.

Methods: This prospective study was conducted from 2015 to2016 in Hamadan province, Iran. Patients with both ischemic and hemorrhagic stroke who were admitted in the first 12 hours were enrolled. The clinical characteristics of the patients were recorded at time of admission as well as on the fourth and the 90th day after stroke. Blood sample was taken and CRP levels were measured at time of admission.

Results: From 186 admitted patients, 155 patients remained in this study for analysis. Mean time between stroke onset and admission was 4.42 hours. Mean level of CRP was 20.03 mg/L. CRP levels in 68 patients (43.8%) were 7 mg/L or above. Prevalence of diabetes (P = 0.001), angina pectoris (P = 0.001), death (P = 0.001), pneumonia (P = 0.004), and DVT (P = 0.002) was significantly higher among patients with CRP levels ≥7 mg/L than patients with CRP levels <7 mg/L. A CRP level ≥7 was associated with poor clinical outcome, including the National Institutes of Health Stroke Scale (NIHSS) ≥13 (P = 0.001) as well as modified Rankin Scale (mRS) >2 (P = 0.004) and Barthel Index (BI) <70 on the first (0.047, 0.001), fourth (0.005, 0.001), and 90th day (0.001, 0.001), respectively.

Conclusion: Our findings indicated that elevated CRP levels in the very early phase of both ischemic and hemorrhagic stroke were associated with poor clinical outcomes and prognosis.


Cite this article as: Mazaheri S, Reisi E, Poorolajal J, Ghiasian M. C-reactive protein levels and clinical outcomes in stroke patients: a prospective cohort study. Arch Iran Med. 2018;21(1):8–12.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2195

Your browser does not support the canvas element.


PDF Download: 1477

Your browser does not support the canvas element.

Submitted: 23 Apr 2017
Accepted: 17 Dec 2017
ePublished: 01 Jan 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)