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Arch Iran Med. 2022;25(7): 422-427.
doi: 10.34172/aim.2022.70
  Abstract View: 240
  PDF Download: 213

Original Article

Clinical Course and Outcome in Children with Congenital Hyperinsulinism

Hedyeh Saneifard 1 ORCID logo, Elham Hajihashemi 2* ORCID logo, Minoo Fallahi 3

1 Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Pediatric Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding Author: Elham Hajihashemi, MD; No 14, Alley 40, Mirdamad St., Esfahan, Iran. Tel:+98 313 2369271; Fax:+98 313 2369271; Email: , Email: elhamhajihashemi@yahoo.com

Abstract

Background: Hyperinsulinism is the most common cause of persistent or recurrent neonatal hypoglycemia that may result in neurological deficits. The treatment goal in these patients is prevention of hypoglycemia to decrease mortality and morbidity. This study was done to determine the clinical course and outcome in children with congenital hyperinsulinism (CHI) referring to Mofid Children’s Hospital from 2011 to 2017.

Methods: This study was done on 22 children with CHI referring to Mofid Children’s Hospital from 2011 to 2017. The demographic, perinatal, clinical, laboratory, imaging, pharmacological, treatment and follow up data of these children were collected and analyzed.

Results: Among 22 children with CHI, the mortality rate was higher among those who received hydrocortisone versus those who did not receive hydrocortisone (46% versus 40%).

Conclusion: According to the results of this study, hydrocortisone had a negative impact on the outcomes of these children, which is important in the management of hypoglycemia. The clinical course and outcome of children with CHI was better with medical compared to surgical treatment.


Cite this article as: Saneifard H, Hajihashemi E, Fallahi M. Clinical course and outcome in children with congenital hyperinsulinism. Arch Iran Med. 2022;25(7):422-427. doi: 10.34172/aim.2022.70
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Submitted: 05 Jun 2020
Revision: 11 Jun 2021
Accepted: 07 Jul 2021
ePublished: 01 Jul 2022
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