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Arch Iran Med. 2020;23(12): 870-879.
doi: 10.34172/aim.2020.116
  Abstract View: 160
  PDF Download: 112

Systematic Review

Mesenchymal Stromal Cells Derived Conditioned Medium in Pulmonary Fibrosis: A Systematic Review and Meta-analysis

Kosar Mohamed Ali 1 ORCID logo, Fattah Hama Rahim Fattah 1, Shirwan Hamasalh Omar 1, Mohammed I M Gubari 2, Mahmoud Yousefifard 3*, Mostafa Hosseini 4,5* ORCID logo

1 College of Medicine, University of Sulaimani, Sulaimani, Iraq
2 Department of Family and Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq
3 Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
4 Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Authors: Mostafa Hosseini, PhD; Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Poursina Ave, Tehran, Iran. Tel: +98-21-88989127; Fax: +98-21-88989127; Email: mhossein110@yahoo.com. Mahmoud Yousefifard, PhD; Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran. Tel: +98-21-86704771; Email: yousefifard.m@iums.ac.ir mhossein110@yahoo.com

Abstract

Background: A definitive conclusion on the efficacy of mesenchymal stromal cells-derived conditioned medium (MSCs-CM) in pulmonary fibrosis has not yet been reached. Therefore, the present meta-analysis intends to investigate the efficacy of MSCs-CM administration on improvement of pulmonary fibrosis.

Methods: An extensive search was performed on the Medline, Embase, Scopus and Web of Science databases by the end of August 2019. Outcomes in the present study included pulmonary fibrosis score, lung collagen deposition, lung collagen expression, transforming growth factor β1 (TGF-β1) expression and interleukin-6 expression. Finally, the data were pooled and an overall standardized mean difference (SMD) with a 95% confidence interval (CI) was reported.

Results: Data from seven studies were included. Analyses showed that administration of MSCs-CM significantly improved pulmonary fibrosis (SMD = -2.36; 95% CI: -3.21, -1.51). MSCs-CM administration also attenuated lung collagen deposition (SMD = -1.70; 95% CI: -2.18, -1.23) and decreased expression of type I collagen (SMD = -6.27; 95% CI: -11.00, -1.55), type III collagen (SMD = -5.16; 95% CI: -9.86, -0.47), TGF- β1 (SMD = -3.36; 95% CI: - 5.62, -1.09) and interleukin-6 (SMD = -1.69; 95% CI: - 3.14, -0.24).

Conclusion: The present meta-analysis showed that administration of MSCs-CM improves pulmonary fibrosis. It seems that the effect of MSCs-CM was mediated by reducing collagen deposition as well as inhibiting the production of inflammatory chemokines such as TGF-β1 and interleukin 6 (IL-6). Since there is no evidence on the efficacy of MSCs-CM in large animals, further studies are needed to translate the finding to clinical studies.

Keywords: Conditioned medium, Lung fibrosis, Stem cells
Cite this article as: Ali KM, Fattah FHR, Omar SH, Gubari MIM, Yousefifard M, Hosseini M. Mesenchymal stromal cells derived conditioned medium in pulmonary fibrosis: a systematic review and meta-analysis. Arch Iran Med. 2020;23(12):870–879. doi: 10.34172/aim.2020.116.
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Abstract View: 160

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Submitted: 04 May 2020
Revision: 20 Jul 2020
Accepted: 04 Aug 2020
ePublished: 01 Dec 2020
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