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Arch Iran Med. 2020;23(12): 864-869.
doi: 10.34172/aim.2020.115
  Abstract View: 286
  PDF Download: 154

COVID-19

Original Article

Clinical Manifestation of Patients Who Died Due to COVID-19; A Retrospective Study from Qom-Iran

Ahmad Hormati 1,2 ORCID logo, Seyed Yaser Foroghi Ghomi 3, Masoudreza Sohrabi 2* ORCID logo, Saeedeh Jafari 1, Amir Jabbari 4, Reza Aminnejad 5, Mahboubeh Afifian 6, Elham RakhshanKhah 2, Sajjad Ahmadpour 1

1 Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Sciences, Qom, Iran
2 Gastrointestinal and Liver Diseases Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran
3 Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran
4 Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran
5 Department of Anesthesiology and clinical care, Qom University of Medical Sciences, Qom, Iran
6 Health Information and Technology, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Masoudreza Sohrabi, MD, PhD; Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Firoozgar Hospital, Tehran, Iran. Tel: +98-21-82141633; Fax: +98-21-82141633; Email: Sohrab_r@yahoo.com

Abstract

Background: The coronavirus disease 2019 (COVID-19) has become a pandemic health problem worldwide. In this study, we attempted to explain the clinical and laboratories characteristics of non-surviving patients, to identify the probable factors affecting disease progression.

Methods: In a retrospective study, we assessed the data from dead adult patients who were hospitalized and laboratory diagnosed with COVID-19 during March 2020. The data were obtained from electronic medical records. Moreover, a checklist including demographic, clinical, laboratorial, imaging, and treatment data was completed for each one of the patients. In case of lack of information, a member of the research team contacted the first-degree relatives via phone.

Results: Totally, 50 patients were enrolled in this study. The mean age was 68.0 ± 14.1 years. Of them, 29 (58%) patients were male. Notably, the median (IQR) hospitalization time was 4.0 (2.7–6.2) days and the duration between the first symptoms to death was 10.0 (5.0–14.5) days. Also, pre-existing morbidity was reported in 42 (84%) patients, and hypertension was the most common one with 28 (54%) patients. Interestingly, body temperature more than 37.5°C was reported in only 20 (40%) patients. Nevertheless, neutrophilia (≥7109/L) and lymphopenia (<1.0 109/L) were observed in 27 (54%) and 29 (58%) patients, respectively. Also, elevated levels of creatinine, lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were common, which may be indicators of aggravation of the patients’ status.

Conclusion: Besides age and underlying diseases, elevated creatinine level, neutrophil count, and the inflammatory indices along with the reduced lymphocyte count can be considered as indicators of disease progression. Hence, they should be considered for admission and surveillance of patients.

Keywords: Clinical manifestation, COVID-19, Iran, Middle East, Mortality
Cite this article as: Alvand S, Mohammadi Z, Rashidian L, Cheraghian B, Rahimi Z, Danehchin L, et al. Irritable bowel syndrome: psychological disorder or poverty? Results of a large cross-sectional study in Iran. Arch Iran Med. 2020;23(12):821–826. doi: 10.34172/aim.2020.109.
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Abstract View: 286

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PDF Download: 154

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Submitted: 27 Apr 2020
Revision: 10 Aug 2020
Accepted: 08 Sep 2020
ePublished: 01 Dec 2020
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