Arch Iran Med. 2019;22(1):24-31.
PMID: 30821157
Scopus id: 85062433567
  Abstract View: 82
  PDF Download: 124

Original Article

Reference Values for Serum Lipid Profiles in Iranian Adults: Tehran Lipid and Glucose Study

Maryam Rahmani 1, Sajad Jeddi 2, Mahboubeh Ghanbari 2, Amir Abbas Momenan 3, Fereidoun Azizi 4, Asghar Ghasemi 2 *

1 Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background: Lipid abnormalities are major risk factors for cardiovascular diseases. In addition to age and sex, other variables can affect serum lipid levels, warranting the determination of population-specific reference values. This study aimed to determine age- and sex-specific reference values for serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TG) in healthy Tehranian adults.

Methods: TC, TG, and HDL-C were measured using the enzymatic colorimetric method and the Friedewald equation (LDL-C = TC − HDL-C − TG/5) was used to calculate LDL-C concentrations in individuals with TG <400 mg/dL. After applying the exclusion criteria, 1147 participants (548 men and 599 women) aged ≥20 years were included. For determining reference values, the International Federation of Clinical Chemistry guidelines (non-parametric method) and the robust method were used for sample sizes ≥120 and <120, respectively.

Results: Reference values for serum TC, LDL-C, HDL-C, and TG were 121.0–261.0, 54.1–175.2, 30.9–71.9, and 46.9–301.2 mg/ dL in men and 117.8–235.9, 49.9–160.9, 36.0–83.9, and 38.1–184.2 mg/dL in women, respectively. All parameters except HDL-C were higher in men than women and showed an increasing trend with age.

Conclusion: Reference values for serum TC, LDL-C, HDL-C, and TG in healthy Tehranian adults were determined, and these values could provide the basis for better decision making in both prevention and clinical settings.

Cite this article as: Rahmani M, Jeddi S, Ghanbari M, Momenan AA, Azizi F, Ghasemi A. Reference values for serum lipid profiles in Iranian adults: Tehran Lipid and Glucose Study. Arch Iran Med. 2019;22(1):24–31.
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Submitted: 10 Jan 2018
Accepted: 28 Oct 2018
First published online: 01 Jan 2019
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