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Arch Iran Med. 2019;22(5): 247-251.
PMID: 31256597
Scopus ID: 85068688254
  Abstract View: 1457
  PDF Download: 895

Original Article

Effect of Various Degrees of Chronic Kidney Disease on Long-term Outcome of Patients with Percutaneous Coronary Intervention

Younes Nozari 1, Akbar Shafiee 1*, Seyed Ebrahim Kassaian 1, Arash Jalali 1, Mehrdad Roozbeh 2, Hadi Safarian 1*

1 Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2 Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Authors: Email: dr_shafiee@alborzi.com; Email: hadisafarian@yahoo.com

Abstract

Background: We aimed to identify the association of degree of renal failure in chronic kidney disease patients who underwent percutaneous coronary intervention (PCI) at our center with 5-year major adverse cardiac events (MACE).

Methods: In this cohort study, we enrolled all patients who underwent primary or elective PCI and completed their 5-year followup unless they developed events related to study end-points. Demographic, angiographic and clinical data of the participants were retrieved from our databank. Glomerular filtration rate (GFR) was calculated based on the Cockcroft-Gault equation for men and women, separately. Accordingly, our patients were classified into three groups: GFR ≥ 60, GFR < 60 and ≥30 and GFR < 30 mL/ min. Then, the demographic and clinical data, as well as the frequency of MACE and its elements, were compared between the study groups.

Results: We included the data for 5,510 patients. MACE occurred in 891 (16.1%) of the patients. A total of 632 cases (16.7%) occurred in patients with GFR > 60 while 224 cases (18.8%) and 35 events (43.7%) occurred in patients with 30 ≤ GFR < 60 and GFR < 30 mL/min, respectively. So, GFR < 30 mL/min was significant predictor for MACE (hazard ratio [HR] = 3.74, 95% CI: 2.64–5.28; P < 0.001). The prediction effect of GFR < 30 remained significant after adjustment for the confounding variables (HR = 3.43, 95% CI: 2.38–4.94; P < 0.001).

Conclusion: GFR <30 mL/min was a strong predictor for 5-year MACE. Moreover, in patients with GFR > 30 mL/min, PCI is a more applicable approach


Cite this article as: Nozari Y, Shafiee A, Kassaian SE, Jalali A, Roozbeh M, Safarian H. Effect of various degrees of chronic kidney disease on long-term outcome of patients with percutaneous coronary intervention. Arch Iran Med. 2019;22(5):247–251.
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Submitted: 30 Dec 2017
Accepted: 28 Dec 2018
ePublished: 01 May 2019
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