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Arch Iran Med. 2020;23(9): 605-613.
doi: 10.34172/aim.2020.71

Scopus ID: 85091811682
  Abstract View: 204
  PDF Download: 169

Original Article

Beneficial Effects of Adding Topical Atorvastatin 5% Cream to Topical Betamethasone 1% Ointment on Chronic Hand Eczema

Maryam Mehrpooya 1 ORCID logo, Fatemeh Ghaed-Amini 1, Farzin Firozian 2, Younes Mohammadi 3, Pedram Alirezaei 4* ORCID logo

1 Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3 Modeling of Non-communicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
4 Psoriasis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Pedram Alirezaei, MD; Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Mirzadeh Eshghi St., Hamadan, 6517838678, Iran. Tel: +98-81-3821868. Fax: +98-81-38381591, Email: prc@umsha.ac.ir

Abstract

Background: Hand eczema (HE) refers to a common inflammatory dermatological condition. Several studies have shown that statins may have anti-inflammatory effects. This study aimed at investigating the efficacy of adding topical atorvastatin to topical betamethasone in the treatment of chronic HE.

Methods: This randomized, double-blind, placebo-controlled research was done between October 2017 and August 2018 in Hamadan, Iran. Of 130 cases treated for HE, 88 were randomly assigned to groups receiving either betamethasone 1% ointment plus atorvastatin 5% cream (n = 44) or betamethasone 1% ointment plus vehicle cream (n=44). Both groups applied their medications twice a day for 10 days. The primary outcome was changes in the severity of HE, assessed by hand eczema severity index (HECSI). The secondary outcomes were changes in itching evaluated via visual analogue scale (VAS) and quality of life examined through dermatology life quality index (DLQI).

Results: Seventy-two out of 88 eligible cases completed the study. The mean HECSI scores decreased in both groups after the intervention, although the change in HECSI was greater in the atorvastatin group (adjusted mean difference [AMD]: 5.756; 95% CI: 5.168 to 6.344, P<0.001). The mean VAS scores decreased in both groups after the intervention, although the change in VAS was greater in the atorvastatin group (AMD: 10.535; 95% CI: 7.005 to 14.064, P<0.001). Treatment with topical atorvastatin was more effective in improving DLQI (AMD: 1.990; 95% CI: 1.821 to 2.158, P<0.001).

Conclusion: Addition of topical atorvastatin to topical betamethasone is beneficial in treatment of chronic HE.

Trial Registration: Identifier: IRCT2017070922965N10; https://www.irct.ir/.

Keywords: Anti-Inflammatory agents, Eczema, Statins
Cite this article as: Mehrpooya M, Ghaed-Amini F, Firozian F, Mohammadi Y, Alirezaei P. Beneficial effects of adding topical atorvastatin 5% cream to topical betamethasone 1% ointment on chronic hand eczema. Arch Iran Med. 2020;23(9):605–613. doi: 10.34172/aim.2020.71.
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Submitted: 09 Sep 2019
Accepted: 14 Mar 2020
ePublished: 01 Sep 2020
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