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Arch Iran Med. 2020;23(8): 530-535.
doi: 10.34172/aim.2020.55
  Abstract View: 107
  PDF Download: 78

Original Article

Comparison of Umbilical Cord Serum Vitamin D Levels between Infants with Transient Tachypnea of the Newborn and those without Respiratory Distress

Hassan Boskabadi 1 ORCID logo, Gholamali Maamouri 1, Farnaz Kalani-moghaddam 2, Mohammad Hosein Ataee Nakhaei 2, Maryam Zakerihamidi 3, Forough Rakhshanizadeh 4 * ORCID logo

1 Department of Pediatrics, Neonatal Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Midwifery, Faculty of Medicine, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran
4 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Forough Rakhshanizadeh, MD; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Tel: +98-9155130386, Email: rakhshanizadehf@mums.ac.ir

Abstract

Background: Transient tachypnea of the newborn (TTN) is one of the most frequent causes of respiratory distress in neonates. A relationship has been shown between vitamin D deficiency and respiratory disorders in neonates. This research was carried out to evaluate the serum level of vitamin D in TTN newborns and their mothers compared to the control group.

Methods: This case-control research was conducted during 2016-2019 in a general hospital affiliated with Mashhad University of Medical Sciences, Iran. Thirty-four infants with TTN and 82 neonates in the control group as well as their mothers were investigated. The levels of umbilical cord serum vitamin D in infants with TTN and also their mothers were compared to the control group.

Results: The mean levels of serum vitamin D in infants with TTN and their mothers were 8.11 ± 4.32 and 12.6 ± 10.12 ng/mL, respectively (P<0.001), whereas they were 19.21 ± 12.71 and 25.96 ± 16.6 ng/mL in the newborns of the control group and their mothers, respectively (P<0.001). The mean differences (95% CI) of neonatal and maternal vitamin D level between the two groups were 11.10 (7.92–14.28) and 13.36 (7.90–18.08), respectively. In the TTN group, 100% of the infants had vitamin D levels less than 30 ng/mL (79.4% had severe, 17.6% had moderate and 2.9% showed mild deficiency). However, vitamin D levels lower than 30 ng/mL were observed in 76.4% of the neonates in the control group (28.8% had severe, 31.1% showed moderate and 16.3% had a mild deficiency) (P<0.001).

Conclusion: The serum vitamin D levels of infants with TTN and their mothers were significantly lower than the control group. Therefore, TTN in infants may be reduced through the treatment of vitamin D deficiency in mothers.

Keywords: Newborn, Respiratory distress, Transient tachypnea of the newborn, Vitamin D deficiency
Cite this article as: Boskabadi H, Maamouri G, Kalani-moghaddam F, Ataee Nakhaei MH, Zakerihamidi M, Rakhshanizadeh F. Comparison of umbilical cord serum vitamin D levels between infants with transient tachypnea of the newborn and those without respiratory distress. Arch Iran Med. 2020;23(8):530–535. doi: 10.34172/aim.2020.55.
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Submitted: 18 Aug 2020
Accepted: 02 Jun 2020
ePublished: 01 Aug 2020
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