Arch Iran Med. 2017;20(1): 0.
PMID: 28112534
Scopus ID: 85009736672
  Abstract View: 1475
  PDF Download: 1060

Case Report

Nicolau Syndrome

Andisheh Maneshi, Saeedeh Ravi, Mohammad Reza Salehi, Maliheh Hasannezhad, Hossein Khalili*
*Corresponding Author: Email: Khalilih@tums.ac.ir


A 23-year-old man was admitted to the hospital with chief complaints of pain, edema and spasm of the left lower limb, as well as mottling of dorsal and plantar aspects of the foot. One week before the current admission, he was treated with oral co–amoxiclav and intramuscular penicillin 6.3.3. Immediately after the third injection, he experienced burning and yellowish discoloration at the site of the injection which then progressed to his leg and foot. Pain, significant edema, spasm and mottling occurred within 30 minutes of the injection. The patient was referred to the hospital after 36 hours from the beginning of symptoms. Color Doppler sonography revealed no impairment in the lower extremity flow and the common femoral artery, superficial femoral, popliteal, dorsalis pedis and posterior tibialis arteries were normal. Superficial probe sonography detected mild effusion in the left ankle without collection.

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ePublished: 01 Jan 2017
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